Organ Systems and Organs

Before one can understand how xenobiotics affect these different body components, it's important to understand normal body components and how they function. For this reason, this section provides a basic overview of anatomy and physiology as it relates to toxicity mechanisms.

Basic Body Structure and Organization

We can think of the basic structure and functional organization of the human body as a pyramid or hierarchical arrangement in which the lowest level of organization (the foundation) consists of cells and chemicals. Organs and organ systems represent the highest levels of the body's organization (Figure 1).

Diagram of a six-layer pyramid to represent the hierarchical organization of human body components into the following, from bottom layer to top: chemicals, cells, tissues, organs, organ systems, and organism.

Figure 1. Pyramid represents a hierarchical organization of human body components
(Image Source: NLM)

Simplified definitions of the various levels of organization within the body are:

  • Organ system — a group of organs that contribute to specific functions within the body. Examples include:
    • Gastrointestinal system
    • Nervous system
  • Organ — a group of tissues precisely arranged so that they can work together to perform specific functions. Examples include:
    • Liver
    • Brain
  • Tissue — a group of cells with similar structure and function. There are only four types of tissues:
    1. Epithelial
    2. Connective
    3. Muscle
    4. Nerve
  • Cell — the smallest living units in the body. Examples include:
    • Hepatocyte
    • Neuron
  • Chemicals — atoms or molecules that are the building blocks of all matter. Examples include:
    • Oxygen
    • Protein

 

In the animation, an image of each level of structural organization of the body is displayed, beginning with chemicals, then cells, then tissues, then organs, then organ systems, and finally, the organism.

Animation 1. Levels of structural organization of the body
(this video has no sound)
(Images obtained from iStock Photos, ©)

 

Organ Systems of the Human Body

The human body consists of eleven organ systems, each of which contains several specific organs. An organ is a unique anatomic structure consisting of groups of tissues that work in concert to perform specific functions. Table 1 includes the structures and functions of these eleven organ systems.

Organ System Functions Organs
Integumentary
  • Barrier to invading organisms and chemicals
  • Temperature control
  • Skin
  • Hair
  • Subcutaneous tissue
Skeletal
  • Supports and moves body
  • Protects internal organs
  • Mineral storage
  • Blood formation
  • Bones
  • Cartilage
  • Ligaments
  • Bone marrow
Muscular
  • Locomotion
  • Heat production
  • Muscles
  • Tendons
Nervous
  • Coordinates activities of other organ systems
  • Responds to sensations
  • Brain
  • Spinal cord
  • Nerves
  • Eyes
  • Ears
Endocrine
  • Regulates body functions by chemicals (hormones)
  • Pituitary gland
  • Parathyroid gland
  • Thyroid gland
  • Adrenal gland
  • Thymus
  • Pancreas
  • Gonads
Cardiovascular
  • Transports oxygen and nutrients to tissues
  • Removes waste products
  • Heart
  • Blood
  • Blood vessels
Lymphatic
  • Returns tissue fluid to blood
  • Defends against foreign organisms
  • Spleen
  • Lymph nodes
  • Thymus
  • Lymphatic vessels
Respiratory
  • Oxygen/carbon dioxide exchange
  • Lungs
  • Trachea
  • Larynx
  • Nasal cavities
  • Pharynx
Digestive
  • Processes foods
  • Absorption of nutrients into body
  • Stomach
  • Intestinal tract
  • Liver
  • Pancreas
  • Esophagus
  • Salivary glands
Urinary
  • Elimination of wastes
  • Regulates pH and volume of blood
  • Kidneys
  • Urinary bladder
  • Urethra
Reproductive
  • Produces germ cells (eggs and sperm)
  • Environment for growth of fetus (female)
  • Ovaries
  • Uterus
  • Mammary glands
  • Testes
  • Prostate gland
  • External genitalia

Table 1. Organ systems of the human body

Knowledge Check

Groups of cells with similar structure and function are known as:
The organ system that transports oxygen and nutrients to tissues and removes waste products is the:
The organ system that regulates body functions by chemicals (hormones) is known as the: